Thursday, February 7, 2013

Grisly scene after Calif. tour bus crash killed 7

Authorities work Monday Feb. 4, 2013, at the scene of Sunday's fatal tour bus crash on Highway 38 north of Yucaipa, Calif., that left at least eight people dead and dozens injured. The cause of the Sunday crash east of Los Angeles remained under investigation. (AP Photo/The Sun, Rick Sforza)

Authorities work Monday Feb. 4, 2013, at the scene of Sunday's fatal tour bus crash on Highway 38 north of Yucaipa, Calif., that left at least eight people dead and dozens injured. The cause of the Sunday crash east of Los Angeles remained under investigation. (AP Photo/The Sun, Rick Sforza)

Authorities work Monday Feb. 4, 2013, at the scene of Sunday's fatal tour bus crash on Highway 38 north of Yucaipa, Calif., that left at least eight people dead and dozens injured. The cause of the Sunday crash east of Los Angeles remained under investigation. (AP Photo/The Sun, Rick Sforza)

Authorities work Monday Feb. 4, 2013, at the scene of Sunday's fatal tour bus crash on Highway 38 north of Yucaipa, Calif., that left at least eight people dead and dozens injured. The cause of the Sunday crash east of Los Angeles remained under investigation. (AP Photo/The Sun, Rick Sforza)

Bolldstains and personal items are seen as an investigator from the National Transpoartation Safety Board photographs a tour bus after an accident that killed at least eight people and 38 more were injured after a tour bus, left, carrying a group from Tijuana, Mexico crashed with two other vehicles just north of Yucaipa, Calif., Sunday, Feb. 3, 2013. (AP Photo/Reed Saxon)

Investigators stand at the scene after a tour bus was lifted back onto the road Monday, Feb. 4, 2013, after it collided with two other vehicles and crashed Sunday, killing at least eight people and injuring 38, just north of Yucaipa, Calif. The bus was carrying a tour group from Tijuana, Mexico. (AP Photo/Reed Saxon)

(AP) ? Gerardo Barrientos and his girlfriend Lluvia Ramirez wanted a week away from the suffering they see every day at a government hospital in Tijuana, Mexico. Looking for a break, they paid $40 apiece for a day trip to the snowy mountains of Southern California.

But when the tour bus they were riding in careened out of control and collided with a car and truck as it came down the mountain from the ski resort town of Big Bear, they found themselves in a scene more gruesome than any they had seen back home.

"I saw many people dead. There are very, very horrendous images in my head, things I don't want to think about," Barrientos, who works in a hospital pharmacy, said Monday.

Authorities said seven people died and three dozen others were injured in the wreck Sunday.

"I was overwhelmed," said Ramirez. "I'm a surgical resident and I usually know how to react, but I was so in shock I didn't know what to do. I just stayed with my friend."

A day after the crash, they were waiting outside the Loma Linda University Medical Center emergency room to hear about the condition of their friend, another medical resident whose neck was broken.

Barrientos, who was uninjured, sprang into action following the crash, moving his friends to safety. He tried to help the bus driver, whose hand was pinned between rocks.

Ramirez, who had a bloody ear, dark bruises and a scratch on her neck, suffered a hairline vertebra fracture.

The severity of the injuries made it difficult for authorities to determine how many people had died. They initially said eight, then reduced the number to seven Monday after determining no more bodies were in the wrecked bus.

The dead included San Diego residents 13-year-old Victor Cabrera-Garcia, Elvira Garcia Jimenez, 40, and Guadalupe Olivas, 61; and Tijuana residents Aleida Adriana Arce Hernandez, 38, Rubicelia Escobedo Flores, 34, and Mario Garcia Santoyo 32, said San Bernardino County coroner's supervisor Tony Campisi. One woman remained unidentified.

Just before the crash, the driver had shouted to the passengers that the brakes had failed, and urged them to call 911.

As passengers frantically tried to get a cellphone signal, a group of teenage girls shrieked and prayed aloud. Others cried and shielded their heads as they careened downhill.

The bus rear-ended a Saturn sedan, swerved, flipped and slid on its side. A Ford pickup in the oncoming lane plowed into it, righting the bus and tossing passengers out shattered windows before it came to a halt.

The crash littered Route 38, a two-lane highway in the San Bernardino National Forest 80 miles east of Los Angeles, with body parts, winter clothing and debris. The bus stood across both lanes with its windows blown out, front end crushed and part of the roof peeled back like a tin can.

Federal investigators at the scene said they would begin on Tuesday a thorough investigation of the bus and the circumstances that surrounded the crash. They will determine if mechanical failure or driver error was to blame.

Government records showed the bus, operated by Scapadas Magicas LLC of National City, Calif., recorded 22 safety violations in inspections in the year ending October ? including brake, windshield and tire problems.

Though the company retained an overall "satisfactory" rating from the Federal Motor Carrier Safety Administration, it had been targeted for a higher rate of inspections linked to bus maintenance, the agency said.

The driver, Norberto B. Perez, 52, of San Ysidro, suffered major injuries but before going to the hospital told authorities the vehicle had brake problems.

A person involved in the investigation who spoke on condition of anonymity because the probe was ongoing said the bus was moving slowly downhill and was passed by other vehicles, including the Saturn, when it suddenly sped up.

The bus traveled about a mile from the point it struck the Saturn until it came to a stop, California Highway Patrol Officer Leon Lopez said.

At least 17 people remained hospitalized Monday, including at least five in critical condition.

The pickup driver was in extremely serious condition, said Peter Brierty, assistant county fire chief.

No one answered the door at the Scapadas Magicas office in a sprawling complex that houses more than 1,300 storage lockers and about 30 small offices.

Jordi Garcia, marketing director of Interbus Tours, said his company rented the bus from Scapadas Magicas, which supplied the driver.

Interbus offers near-daily bus tours to the western U.S. from Tijuana. Its office in a Tijuana strip mall displays photographs of some of its destinations, including Hollywood, the Las Vegas Strip and the San Diego Zoo.

Garcia said 38 people were aboard the bus that crashed, including the driver and a tour guide. The bus left Tijuana at 5 a.m. Sunday and planned to return late that night.

He said he spoke briefly with his tour guide, who suffered bruises. She told him she heard a loud pop before the crash.

Maria Salazar's daughter, 28-year-old Diana Maldonado of San Diego, was among those injured. Salazar said her daughter described the terror of the bus flipping and her head smashing through a window as she was propelled out of the vehicle. She lost consciousness and awoke as paramedics tended to her.

Maldonado hurt her back and shoulder but did not break any bones, according to her mother, who said her two other daughters had planned to make the trip but did not.

"I just thank God they did not go," Salazar said in Spanish as she choked back tears.

___

Associated Press reporters contributing to this report included Julie Watson in San Diego, Raquel Maria Dillon in San Bernardino County and Michael R. Blood, Andrew Dalton and Bob Jablon in Los Angeles. Flaccus reported from Loma Linda, Calif.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-02-05-Tour%20Bus-Crash/id-c85b3dd80ee9449a9959125b9850e8d7

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Tuesday, February 5, 2013

Safely Explore an Erupting Volcano With This Stunning 360 Degree Interactive Video

A few days ago we posted a behind the scenes look at how the Moscow-based Airpano managed to capture some spectacular footage and imagery of the Tolbachick volcano using a flying drone. But it turns out they also had a 360 degree video camera mounted to one of their helicopters. And the footage of their flight over the volcano and its lava flows has now been posted online for you to explore and drool over. Nature: you still make for some awe-inspiring footage. [Spiegel via Fazed] More »


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HP?s Chromebook: Bigger Screen, More Money, Less Battery Life

HP’s Chromebook: Bigger Screen, More Money, Less Battery Life
Hewlett-Packard is now in the Chromebook business. On Monday, HP announced it's first Chrome OS device, the Pavilion Chromebook. And, on paper, HP's first Chromebook looks to be bit of a mixed bag.

Source: http://feedproxy.google.com/~r/GearFactor/~3/1UIpER_wWME/

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U.S., allies warn North Korea against 'provocative' moves (CNN)

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Monday, February 4, 2013

Iran hedges on nuclear talks with six powers or U.S.

MUNICH (Reuters) - Iran said on Sunday it was open to a U.S. offer of direct talks on its nuclear program and that six world powers had suggested a new round of nuclear negotiations this month, but without committing itself to either proposal.

Diplomatic efforts to resolve a dispute over Iran's nuclear program, which Tehran says is peaceful but the West suspects is intended to give Iran the capability to build a nuclear bomb, have been all but deadlocked for years, while Iran has continued to announce advances in the program.

Iranian Foreign Minister Ali Akbar Salehi said a suggestion on Saturday by U.S. Vice President Joe Biden that Washington was ready for direct talks with Iran if Tehran was serious about negotiations was a "step forward".

"We take these statements with positive consideration. I think this is a step forward but ... each time we have come and negotiated it was the other side unfortunately who did not heed ... its commitment," Salehi said at the Munich Security Conference where Biden made his overture a day earlier.

He also complained to Iran's English-language Press TV of "other contradictory signals", pointing to the rhetoric of "keeping all options on the table" used by U.S. officials to indicate they are willing to use force to keep Iran from obtaining a nuclear weapon.

"This does not go along with this gesture (of talks) so we will have to wait a little bit longer and see if they are really faithful this time," Salehi said.

Iran is under a tightening web of sanctions. Israel has also hinted it may strike if diplomacy and international sanctions fail to curb Iran's nuclear drive.

In Washington, Army General Martin Dempsey, the top U.S. military officer, said in an interview broadcast on Sunday that the United States has the capability to stop any Iranian effort to build nuclear weapons, but Iranian "intentions have to be influenced through other means."

Dempsey, chairman of the Joint Chiefs of Staff, made his comments on NBC's program "Meet the Press," speaking alongside outgoing Defense Secretary Leon Panetta.

Panetta said current U.S. intelligence indicated that Iranian leaders have not made a decision to proceed with the development of a nuclear weapon.

"But every indication is they want to continue to increase their nuclear capability," he said. "And that's a concern. And that's what we're asking them to stop doing."

The new U.S. secretary of state, John Kerry, has said he will give diplomacy every chance of solving the Iran standoff.

THE BEST CHANCE

With six-power talks making little progress, some experts say talks between Tehran and Washington could be the best chance, perhaps after Iran has elected a new president in June.

Negotiations between Iran and the six powers - Russia, China, the United States, Britain, France and Germany - have been deadlocked since a meeting last June.

EU officials have accused Iran of dragging its feet in weeks of haggling over the date and venue for new talks.

Salehi said he had "good news", having heard that the six powers would meet in Kazakhstan on February 25.

A spokesman for EU foreign policy chief Catherine Ashton, who coordinates the efforts of the six powers, confirmed that she had proposed talks in the week of February 25 but noted that Iran had not yet accepted.

Kazakhstan said it was ready to host the talks in either Astana or Almaty.

Salehi said Iran had "never pulled back" from the stuttering negotiations with the six powers. "We still are very hopeful. There are two packages, one package from Iran with five steps and the other package from the (six powers) with three steps."

Iran raised international concern last week by announcing plans to install and operate advanced uranium enrichment machines. The EU said the move, potentially shortening the path to weapons-grade material, could deepen doubts about the peaceful nature of Iran's nuclear program.

Prime Minister Benjamin Netanyahu said on Sunday that Israel's mission to stop its arch-enemy from acquiring nuclear weapons was "becoming more complex, since the Iranians are equipping themselves with cutting-edge centrifuges that shorten the time of (uranium) enrichment".

"We must not accept this process," said Netanyahu, who is trying to form a new government after winning an election last month. Israel is generally believed to be the only country in the Middle East with nuclear weapons.

(Additional reporting by Myra MacDonald and Stephen Brown in Munich, Dmitry Solovyov in Almaty, Yeganeh Torbati in Dubai and Jim Wolf in Washington; Editing by Kevin Liffey and Will Dunham)

Source: http://news.yahoo.com/iran-hedges-nuclear-talks-six-powers-u-184256628.html

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Friday, February 1, 2013

Beer's bitter compounds could help brew new medicines

Wednesday, January 30, 2013

Researchers employing a century-old observational technique have determined the precise configuration of humulones, substances derived from hops that give beer its distinctive flavor.

That might not sound like a big deal to the average brewmaster, but the findings overturn results reported in scientific literature in the last 40 years and could lead to new pharmaceuticals to treat diabetes, some types of cancer and other maladies.

"Now that we have the right results, what happens to the bitter hops in the beer-brewing process makes a lot more sense," said Werner Kaminsky, a University of Washington research associate professor of chemistry.

Kaminsky is the lead author of a paper describing the findings, published this month in the journal Angewandte Chemie International Edition.

There is documentation that beer and its bittering acids, in moderation, have beneficial effects on diabetes, some forms of cancer, inflammation and perhaps even weight loss.

Kaminsky used a process called X-ray crystallography to figure out the exact structure of those acids, humulone molecules and some of their derivatives, produced from hops in the brewing process. That structure is important to researchers looking for ways to incorporate those substances, and their health effects, into new pharmaceuticals.

Humulone molecules are rearranged during the brewing process to contain a ring with five carbon atoms instead of six. At the end of the process two side groups are formed that can be configured in four different ways ? both groups can be above the ring or below, or they can be on opposite sides.

Which of the forms the molecule takes determines its "handedness," Kaminsky said, and that is important for understanding how a particular humulone will react with another substance. If they are paired correctly, they will fit together like a nut and bolt.

If paired incorrectly, they might not fit together at all or it could be like placing a right hand into a left-handed glove. That could produce disastrous results in pharmaceuticals.

Kaminsky cited thalidomide, which has a number of safe uses but was famously used to treat morning sickness in pregnant women in the late 1950s and early 1960s before it was discovered to cause birth defects. Molecule "handedness" in one form of the drug was responsible for the birth defects, while the orientation of molecules in another form did not appear to have the negative effects.

To determine the configuration of humulones formed in the brewing process, coauthors Jan Urban, Clinton Dahlberg and Brian Carroll of KinDex Therapeutics, a Seattle pharmaceutical firm that funded the research, recovered acids from the brewing process and purified them.

They converted the humulones to salt crystals and sent them to Kaminsky, who used X-ray crystallography ? a technique developed in the early 20th century ? to determine the exact configuration of the molecules.

"Now that we know which hand belongs to which molecule, we can determine which molecule goes to which bitterness taste in beer," Kaminsky said.

The authors point out that while "excessive beer consumption cannot be recommended to propagate good health, isolated humulones and their derivatives can be prescribed with documented health benefits."

Some of the compounds have been shown to affect specific illnesses, Kaminsky said, while some with a slight difference in the arrangement of carbon atoms have been ineffective.

The new research sets the stage for finding which of those humulones might be useful in new compounds to be used as medical treatments.

###

University of Washington: http://www.uwnews.org

Thanks to University of Washington for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126532/Beer_s_bitter_compounds_could_help_brew_new_medicines

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